Common Variable Immunodeficiency Disease (CVID) – Mystery Diagnosis

Common variable immunodeficiency (CVID) (also known as Acquired hypogammaglobulinemia) is a group of approximately 150 primary immunodeficiencies (PIDs), which have a common set of features (including hypogammaglobulinemia) but which have different underlying causes.

Common variable immunodeficiency is the most commonly encountered primary immunodeficiency.

CVID Symptoms & Diagnosis:

Symptoms

CVID can be diagnosed anytime from childhood through adulthood.

As with other antibody deficiencies, the most common types of recurrent infections involve the ears, sinuses, nose, bronchi and lungs. These include:
• Pneumonia
• Sinusitis
• Ear infections
• Gastrointestinal infections

Recurrent pneumonia and chronic infections in the lungs can lead to lung damage called bronchiectasis, which can complicate treatment.

Diagnosis

CVID may be suspected in children or adults with a history of recurrent infections involving the lungs, bronchi, ears or sinuses.

An accurate diagnosis can be made through screening tests that measure immunoglobulin levels or the number of B cells in the blood.

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